Structure via PubChem · Public domain (PubChem)
desvenlafaxine
Sign in to saveAlso known as WY-45233, 1-[2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol, O-desmethylvenlafaxine, ODV, (±)-desvenlafaxine
Desvenlafaxine, sold under the brand name Pristiq among others, is a medication used to treat depression. It is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class and is taken by mouth. It is recommended that the need for further treatment be occasionally reassessed. Studies have shown similar effectiveness compared to its parent compound venlafaxine.
Chemical data
- Formula
- C16H25NO2
- Molecular weight
- 263.37 g/mol
- IUPAC name
- 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
- SMILES
- CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
- InChIKey
- KYYIDSXMWOZKMP-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 43.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2008
- Admin. routes
- oral
- Indications
- fibromyalgia, chronic hepatitis C virus infection, major depressive disorder, depressive disorder
via ChEMBL · EBI
Wikidata facts
- Subclass of
- medication
- Mass
- 263.188529
Show 9 more facts
- chemical formula
- C₁₆H₂₅NO₂
- defined daily dose
- 50.0
- significant drug interaction
- tranylcypromine
- canonical SMILES
- CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
- World Health Organisation international non-proprietary name
- desvenlafaxine
- subject has role
- adrenergic uptake inhibitors
- medical condition treated
- anxiety
- Commons category
- Desvenlafaxine
- legal status (medicine)
- boxed warning
via Wikidata · CC0
~6 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Adverse effects
- Pharmacology
- Approval status
- United States
- Canada
- European Union
- Australia
- See also
- References
Desvenlafaxine, sold under the brand name Pristiq among others, is a medication used to treat depression. It is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class and is taken by mouth. It is recommended that the need for further treatment be occasionally reassessed. Studies have shown similar effectiveness compared to its parent compound venlafaxine.
Common side effects include dizziness, trouble sleeping, increased sweating, constipation, sleepiness, anxiety, and sexual problems. Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and high blood pressure. There is a high risk of withdrawal syndrome which may occur if the dose is decreased or the medication is completely stopped. It is unclear if use during pregnancy or breastfeeding is safe.
Excerpted from Wikipedia’s “desvenlafaxine” article, available under the CC BY-SA 4.0 licence.