fluorometholone

Also known as FLP469, (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one, FML, 9-fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

Fluorometholone (INN, BAN, JAN) (brand names Efflumidex, Flucon, FML Forte, FML, others), also known as 6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione, is a synthetic glucocorticoid which is used in the treatment of inflammatory eye diseases. The C17α acetate ester, fluorometholone acetate (brand name Flarex), is also a glucocorticoid and is used for similar indications.

In the Vinony graph

Vinony's link graph records 744 inbound references to fluorometholone, and connects out to mometasone furoate, fludrocortisone and ulipristal acetate.

It sits within the topics Drugboxes which contain changes to verified fields, Drugboxes which contain changes to watched fields and Drugs developed by Novartis.

Vinony links it to 18 Wikipedia language editions.

Chemical data

Formula: C22H29FO4
Molecular weight: 376.5 g/mol
IUPAC name: (6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@]2([C@@]4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O
InChIKey: FAOZLTXFLGPHNG-KNAQIMQKSA-N
XLogP: 2
Polar surface area: 74.6 Å²
H-bond donors: 2
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1972
Admin. routes: topical
Indications: acne, eye inflammation, dry eye syndrome, hemorrhoid

via ChEMBL · EBI

Research

572 papers

Fluorometholone.2006
Fluorometholone modulates gene expression of ocular surface mucins.Acta ophthalmologica · 2019
Fluorometholone inhibits corneal epithelial proliferation, migration via targeting Rho GTPases: RhoA, Rac1, and Cdc42.Experimental eye research · 2025
The FLuorometholone as Adjunctive MEdical Therapy for Trachomatous Trichiasis Surgery (FLAME) Trial: Study Design.Ophthalmic epidemiology · 2024
Fluorometholone 0.1% as Ancillary Therapy for Trachomatous Trichiasis Surgery: Randomized Clinical Trial.American journal of ophthalmology · 2019

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 376.205
Has use: medication

Show 6 more facts

chemical formula: C₂₂H₂₉FO₄
medical condition treated: inflammation
isomeric SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@]2([C@@]4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O
canonical SMILES: CC1CC2C3CCC(C3(CC(C2(C4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O
World Health Organisation international non-proprietary name: fluorometholone
Commons category: Fluorometholone

Sources (3)

via Wikidata · CC0

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