halothane

Also known as 2-bromo-2-chloro-1,1,1-trifluoroethane, 2,2,2-trifluoro-1-chloro-1-bromoethane, 1-bromo-1-chloro-2,2,2-trifluoroethane, 1,1,1-trifluoro-2-chloro-2-bromoethane, 1,1,1-trifluoro-2-bromo-2-chloroethane, bromochlorotrifluoroethane

Halothane (bromochlorotrifluoroethane), sold under the brand name Fluothane among others, is a halocarbon with the chemical formula . It is used as a general anaesthetic given by inhalation. It can be used to induce or maintain anaesthesia. Its use in developed countries has been mostly replaced by newer anesthetic agents such as sevoflurane. One of its benefits is that it does not increase the production of saliva, which can be particularly useful in those who are difficult to intubate.

In the Vinony graph

Vinony's link graph records 2,738 inbound references to halothane, and connects out to ginkgolide, picrotoxin and inhalational anaesthetic.

It sits within the topics 5-HT3 receptor positive allosteric modulators, ECHA InfoCard ID from Wikidata and GABAA receptor positive allosteric modulators.

Vinony links it to 42 Wikipedia language editions.

Key facts

Drug.verifiedrevid: 443852402
Drug.image: 2-bromo-2-chloro-1,1,1-trifluoroethane 200.svg
Drug.image_class: skin-invert-image
Drug.width: 120
Drug.image2: Halothane-3D-vdW.png
Drug.image_class2: bg-transparent
Drug.width2: 120
Drug.tradename: Fluothane, Somnothane, Rhodialothan
Drug.DailyMedID: Halothane
Drug.routes_of_administration: Inhalation
Drug.class: Volatile anesthetic
Drug.ATC_prefix: N01
Drug.ATC_suffix: AB01
Drug.legal_BR: C1
Drug.legal_US: Rx-only
Drug.metabolism: Hepatic (CYP2E1)
Drug.excretion: Kidney, respiratory
Drug.CAS_number: 151-67-7

via Wikipedia infobox

Chemical data

Formula: C2HBrClF3
Molecular weight: 197.38 g/mol
IUPAC name: 2-bromo-2-chloro-1,1,1-trifluoroethane
SMILES: C(C(F)(F)F)(Cl)Br
InChIKey: BCQZXOMGPXTTIC-UHFFFAOYSA-N
XLogP: 2.3
Polar surface area: 0 Å²
H-bond donors: 0
H-bond acceptors: 3
Formal charge: 0

via PubChem

Research

19,814 papers

Halothane hepatitis: what's new?Drugs · 1980
Halothane hepatitis. Current concepts.Postgraduate medicine · 1974
The halothane hepatitis that was not.British journal of anaesthesia · 2020
Halothane hepatitis: a model of immune mediated drug hepatotoxicity.Clinical science (London, England : 1979) · 1987
Halothane hepatitis and the anaesthesiologist.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 1984

via PubMed

Wikidata facts

Mass: 195.890224

Show 13 more facts

chemical formula: C₂HBrClF₃
melting point: -180
NIOSH Pocket Guide ID: 0310
density: 1.87
boiling point: 122
vapor pressure: 243
solubility: 0.3
ceiling exposure limit: 16.2
World Health Organisation international non-proprietary name: 氟烷
Commons category: Halothane
canonical SMILES: C(C(F)(F)F)(Cl)Br
MCN code: 2903.79.31
global warming potential: 50

Sources (10)

via Wikidata · CC0

~10 min read

Encyclopedic overview

13 sections

Contents

Medical uses
Side effects
Occupational safety
Pharmacology
Chemical and physical properties
Synthesis
Related substances
History
Society and culture
Availability
Greenhouse gas
Ozone depletion
References

Side effects include an irregular heartbeat, respiratory depression, and hepatotoxicity. Like all volatile anesthetics, it should not be used in people with a personal or family history of malignant hyperthermia. It appears to be safe in porphyria. It is unclear whether its usage during pregnancy is harmful to the fetus, and its use during a C-section is generally discouraged. Halothane is a chiral molecule that is used as a racemic mixture.

Excerpted from Wikipedia’s “halothane” article, available under the CC BY-SA 4.0 licence.