HDAC6
Sign in to saveAlso known as CPBHM, HD6, PPP1R90, JM21, histone deacetylase 6
Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene. HDAC6 has emerged as a highly promising candidate to selectively inhibit as a therapeutic strategy to combat several types of cancer and neurodegenerative disorders.
In the Vinony graph
Vinony's link graph records 19 inbound references to HDAC6, and connects out to PubMed, Ensembl genome database project and activation induced cytidine deaminase.
It sits within the topics EC 3.5.1 and Genes on human chromosome X.
Vinony links it to 6 Wikipedia language editions.
Gene data
HDAC6- Name
- histone deacetylase 6
- Type
- protein-coding
- Chromosome
- X
- Position
- 48,801,372–48,824,986 (+)
- Aliases
- CPBHM, HD6, JM21, KDAC6, PPP1R90
- Ensembl
- ENSG00000094631
- RefSeq RNA
- NM_001321225.2, NM_001321226.2, NM_001321227.2, NM_001321228.2, NM_001321229.1
- RefSeq protein
- NP_001308154.1, NP_001308155.1, NP_001308156.1, NP_001308157.1, NP_001308158.1
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
histone deacetylase 6
- Symbol
- HDAC6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:48,801,372-48,824,986
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein HDAC6 PDB 3C5K.png
Show 8 more facts
- HomoloGene ID
- 31353
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10013
- chromosome
- human X chromosome
- genomic start
- 48659784
- genomic end
- 48683392
- cytogenetic location
- Xp11.23
- expressed in
- ganglionic eminence
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Function
- Clinical relevance
- Interactions
- See also
- References
- Further reading
- External links
Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene. HDAC6 has emerged as a highly promising candidate to selectively inhibit as a therapeutic strategy to combat several types of cancer and neurodegenerative disorders.
== Function ==
Excerpted from Wikipedia’s “HDAC6” article, available under the CC BY-SA 4.0 licence.