HDAC6
Sign in to saveAlso known as CPBHM, HD6, PPP1R90, JM21, histone deacetylase 6
Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene. HDAC6 has emerged as a highly promising candidate to selectively inhibit as a therapeutic strategy to combat several types of cancer and neurodegenerative disorders.
Gene data
HDAC6- Name
- histone deacetylase 6
- Type
- protein-coding
- Chromosome
- X
- Position
- 48,801,377–48,824,986 (+)
- Aliases
- CPBHM, HD6, JM21, KDAC6, PPP1R90
- Ensembl
- ENSG00000094631
- RefSeq RNA
- NM_001321225.2, NM_001321226.2, NM_001321227.2, NM_001321228.2, NM_001321229.1
- RefSeq protein
- NP_001308154.1, NP_001308155.1, NP_001308156.1, NP_001308157.1, NP_001308158.1
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein HDAC6 PDB 3C5K.png
Show 5 more facts
- HomoloGene ID
- 31353
- exact match
- identifiers.org/ncbigene/10013
- genomic start
- 48659784
- genomic end
- 48683392
- cytogenetic location
- Xp11.23
via Wikidata · CC0
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Article
7 sectionsContents
- Function
- Clinical relevance
- Interactions
- See also
- References
- Further reading
- External links
Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene. HDAC6 has emerged as a highly promising candidate to selectively inhibit as a therapeutic strategy to combat several types of cancer and neurodegenerative disorders.
== Function ==