idoxuridine
Sign in to saveIdoxuridine is an anti-herpesvirus antiviral drug.
Research
2,954 papers- Therapeutics. XIV. Herpes simplex virus infections and idoxuridine.The British journal of dermatology · 1971
- TO-DAY'S DRUGS. IDOXURIDINE.British medical journal · 1964
- HYDROLYSIS OF IDOXURIDINE.Journal of pharmaceutical sciences · 1964
- Ineffectiveness of topical idoxuridine in dimethyl sulfoxide for therapy for genital herpes.JAMA · 1982
- IDOXURIDINE--A PRELIMINARY REPORT.Journal of pharmaceutical sciences · 1964
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Article
7 sectionsContents
- Clinical use
- Side effects
- Formulations and dosage
- Synthesis
- See also
- References
- Further reading
Idoxuridine is an anti-herpesvirus antiviral drug.
It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing. It is used only topically due to cardiotoxicity. It was synthesized by William Prusoff in the late 1950s. Initially developed as an anticancer drug, idoxuridine became the first antiviral agent in 1962.