KLK14

Also known as KLK-L6, kallikrein related peptidase 14

Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.

Gene data

KLK14

Name: kallikrein related peptidase 14
Type: protein-coding
Position: 51,077,317–51,086,530 (−)
Aliases: KLK-L6
Ensembl: ENSG00000129437
RefSeq RNA: NM_001311182.2, NM_001369775.2, NM_022046.6, NR_163144.1, XM_017026820.2
RefSeq protein: NP_001298111.2, NP_001356704.1, NP_071329.3, XP_016882309.1, XP_054177022.1

This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].

Gene Ontology

Biological process

proteolysis proteolysis fertilization negative regulation of G protein-coupled receptor signaling pathway positive regulation of G protein-coupled receptor signaling pathway epidermis morphogenesis protein maturation seminal clot liquefaction

Molecular function

serine-type endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase activity hydrolase activity

Cellular component

extracellular region extracellular region extracellular region extracellular region secretory granule

Pathways

Developmental Biology Keratinization Formation of the cornified envelope

via MyGene.info

Wikidata facts

Show 5 more facts

HomoloGene ID: 69348
exact match: identifiers.org/ncbigene/43847
genomic end: 51587502
genomic start: 51580752
cytogenetic location: 19q13.41

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Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer, skin disorders and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Apart from its common transcript, an additional transcript variant has been described but its difference in function and full length nature has not been determined.