Structure via PubChem · Public domain (PubChem)
methsuximide
Sign in to saveAlso known as Celontin®, Petinutin®, 1,3-Dimethyl-3-phenylsuccinimide, Methsuximid, N,2-Dimethyl-2-phenylsuccinimide, Mesuximida, 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione, Mesuximide
Mesuximide (or methsuximide, methosuximide) is a succinimide anticonvulsant medication. It is sold as a racemate by Pfizer under the tradenames Petinutin (Switzerland) and Celontin (United States). The therapeutic efficacy of methosuximide is largely due to its pharmacologically active metabolite, N-desmethylmethosuximide, which has a longer half-life and attains much higher plasma levels than its parent.
In the Vinony graph
Within Vinony's link graph, methsuximide is referenced by 400 other articles, and connects out to racemate, liver and urine.
Vinony files it under Anticonvulsants, Drugboxes which contain changes to verified fields and Drugs developed by Pfizer.
Its subject is documented across 11 Wikipedia language editions.
Chemical data
- Formula
- C12H13NO2
- Molecular weight
- 203.24 g/mol
- IUPAC name
- 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
- SMILES
- CC1(CC(=O)N(C1=O)C)C2=CC=CC=C2
- InChIKey
- AJXPJJZHWIXJCJ-UHFFFAOYSA-N
- XLogP
- 1.2
- Polar surface area
- 37.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1957
- Admin. routes
- oral
- Indications
- epilepsy, Seizure
via ChEMBL · EBI
Research
113 papers- Methsuximide.2012
- Methsuximide for refractory complex partial seizures.Neurology · 1981
- Methsuximide-induced movement disorder.Pediatrics · 1991
- Methsuximide reduces valproic acid serum levels.Therapeutic drug monitoring · 2001
- Methsuximide lowers lamotrigine blood levels: A pharmacokinetic antiepileptic drug interaction.Epilepsia · 2000
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 203.095
- Has use
- medication
Show 6 more facts
- defined daily dose
- 0.9
- chemical formula
- C₁₂H₁₃NO₂
- medical condition treated
- epilepsy
- canonical SMILES
- CC1(CC(=O)N(C1=O)C)C2=CC=CC=C2
- subject has role
- anticonvulsant agent
- Commons category
- Mesuximide
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Medical use
- References
Mesuximide (or methsuximide, methosuximide) is a succinimide anticonvulsant medication. It is sold as a racemate by Pfizer under the tradenames Petinutin (Switzerland) and Celontin (United States). The therapeutic efficacy of methosuximide is largely due to its pharmacologically active metabolite, N-desmethylmethosuximide, which has a longer half-life and attains much higher plasma levels than its parent.
==Medical use== The medical use is indicated for the control of absence seizures that are refractory to other drugs.
Excerpted from Wikipedia’s “methsuximide” article, available under the CC BY-SA 4.0 licence.