nemonapride

Also known as (±)-nemonapride, cis-nemonapride, Emilace, rel-5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide

Nemonapride, also previously known as emonapride and sold under the brand name Emilace, is an atypical antipsychotic which is used in the treatment of schizophrenia. It is taken by mouth.

In the Vinony graph

Within Vinony's link graph, nemonapride is referenced by 618 other articles, and connects out to fluphenazine, zuclopenthixol and pipotiazine.

It is catalogued under topics including 5-HT1A agonists, Atypical antipsychotics and Benzamides.

Its subject is documented across 8 Wikipedia language editions.

Research

314 papers

[3H]nemonapride binding in human caudate and putamen.Brain research bulletin · 1997
Associations between side effects of nemonapride and plasma concentrations of the drug and prolactin.Progress in neuro-psychopharmacology & biological psychiatry · 2002
Multiple [3H]-nemonapride binding sites in calf brain.Naunyn-Schmiedeberg's archives of pharmacology · 1997
Nemonapride for the treatment of schizophrenia.The American journal of psychiatry · 1997
High-performance liquid chromatographic determination of nemonapride and desmethylnemonapride in human plasma using an electrochemical detection.Journal of chromatography. B, Biomedical sciences and applications · 1998

via PubMed

Wikidata facts

Mass: 387.171354752

Show 4 more facts

canonical SMILES: O=C(NC1CCN(CC=2C=CC=CC2)C1C)C=3C=C(Cl)C(=CC3OC)NC
isomeric SMILES: C(N[C@H]1[C@@H](C)N(CC2=CC=CC=C2)CC1)(=O)C3=C(OC)C=C(NC)C(Cl)=C3
chemical formula: C₂₁H₂₆ClN₃O₂
Commons category: Nemonapride

Sources (2)

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Encyclopedic overview

14 sections

Contents

Medical uses
Available forms
Side effects
Pharmacology
Pharmacodynamics
Pharmacokinetics
Chemistry
Structure and stereochemistry
History
Society and culture
Names
Availability
See also
References

Nemonapride, also previously known as emonapride and sold under the brand name Emilace, is an atypical antipsychotic which is used in the treatment of schizophrenia. It is taken by mouth.

Side effects of nemonapride include akathisia, dystonia, hypokinesia, tremor, hypersalivation, and hyperprolactinemia, among others. The drug acts as a dopamine D2, D3, and D4 receptor antagonist. To a lesser extent, it is also a serotonin 5-HT1A receptor partial agonist. Structurally, nemonapride is a benzamide derivative and is related to sulpiride and other benzamides.

Excerpted from Wikipedia’s “nemonapride” article, available under the CC BY-SA 4.0 licence.