Structure via PubChem · Public domain (PubChem)
pralatrexate
Sign in to saveAlso known as Folotyn®, PDX, (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid, N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid, (2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid, HSDB 7786, 10-Propargyl-10-deazaaminopterin
Pralatrexate, sold under the brand name Folotyn, is a medication used for the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL).
In the Vinony graph
Vinony's link graph records 465 inbound references to pralatrexate, and connects out to chemotherapy, intravenous infusion and defusion and tiazofurin.
Vinony files it under Antifolates, Drugboxes which contain changes to verified fields and ECHA InfoCard ID from Wikidata.
Vinony links it to 15 Wikipedia language editions.
Chemical data
- Formula
- C23H23N7O5
- Molecular weight
- 477.5 g/mol
- IUPAC name
- (2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid
- SMILES
- C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
- InChIKey
- OGSBUKJUDHAQEA-WMCAAGNKSA-N
- XLogP
- -0.9
- Polar surface area
- 207 Ų
- H-bond donors
- 5
- H-bond acceptors
- 11
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2009
- Admin. routes
- parenteral
- Indications
- unspecified peripheral T-cell lymphoma, neoplasm, lymphoma, multiple myeloma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- unsaturated compound
- Mass
- 477.176067
- Has use
- medication
Show 8 more facts
- chemical formula
- C₂₃H₂₃N₇O₅
- isomeric SMILES
- C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
- canonical SMILES
- C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
- World Health Organisation international non-proprietary name
- pralatrexate
- subject has role
- protein synthesis inhibitor
- physically interacts with
- dihydrofolate reductase
- stylized name
- PRALAtrexate
- Commons category
- Pralatrexate
via Wikidata · CC0
~6 min read
Encyclopedic overview
12 sectionsContents
- Medical uses
- Available forms
- Side effects
- Mechanism of action
- Discovery
- Society and culture
- Legal status
- US approval
- EU rejection
- Economics
- References
- External links
{{Drugbox | Verifiedfields = changed | verifiedrevid = 461750802 | image = Pralatrexate.png | image_class = skin-invert-image | width = 300 | image2 = Pralatrexate ball-and-stick.png | image_class2 = bg-transparent | width2 = 300
| tradename = Folotyn | Drugs.com = | licence_US = Pralatrexate | pregnancy_AU = | pregnancy_category = | routes_of_administration = Intravenous | ATC_prefix = L01 | ATC_suffix = BA05
Excerpted from Wikipedia’s “pralatrexate” article, available under the CC BY-SA 4.0 licence.