Genes on human chromosome 1

NLR family pyrin domain containing 3 (NLRP3) is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1. NLRP3 has previously been known as NACHT, LRR, and PYD domains-containing protein 3 [NALP3]; cryopyrin; cold induced autoinflammatory syndrome 1 (CIAS1), caterpillar-like receptor 1.1 (CLR1.1), and PYRIN-containing APAF1-like protein 1 (PYPAF1).

protein-coding gene in the species Homo sapiens

class of enzymes

class of enzymes

mammalian protein found in Homo sapiens

mammalian protein found in Homo sapiens

P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.

mammalian protein found in Homo sapiens

Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.

class of enzymes

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1) is a protein that in humans is encoded by the TACSTD2 gene.

CD30, also known as TNFRSF8 (TNF receptor superfamily member 8), is a cell membrane protein of the tumor necrosis factor receptor family and a tumor marker for Hodgkin lymphoma and anaplastic large cell lymphoma.

Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.

protein-coding gene in the species Homo sapiens

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the SRGAP2 gene. It is involved in neuronal migration and differentiation and plays a critical role in synaptic development, brain mass and number of cortical neurons. Downregulation of srGAP2 inhibits cell–cell repulsion and enhances cell–cell contact duration.

CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells. CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily (IgSF) involved in antibody-dependent cellular cytotoxicity (ADCC). It can be used to isolate populations of specific immune cells through fluorescent-activated cel

GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle, testis, kidney, fat tissue (adipocytes), and brain.

class of enzymes

Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene.

protein-coding gene in the species Homo sapiens

class of enzymes

mammalian protein found in Homo sapiens

protein-coding gene in the species Homo sapiens

protein family

protein-coding gene in the species Homo sapiens

family of lipid-gated inward-rectifier potassium ion channels

SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene. SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.

mammalian protein found in Homo sapiens

protein-coding gene in the species Homo sapiens

Nidogen-1 (NID-1), formerly known as entactin, is a protein that in humans is encoded by the NID1 gene. Both nidogen-1 and nidogen-2 are essential components of the basement membrane alongside other components such as type IV collagen, proteoglycans (heparan sulfate and glycosaminoglycans), laminin and fibronectin.

Neurofascin is a protein that in humans is encoded by the NFASC gene.

Enolase 1 (ENO1), more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase, in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1.

Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.

The double-stranded RNA-specific adenosine deaminase enzyme family are encoded by the ADAR family genes. ADAR stands for adenosine deaminase acting on RNA. This article focuses on the ADAR proteins; This article details the evolutionary history, structure, function, mechanisms and importance of all proteins within this family.

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

InterPro Family

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.

Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.

Kisspeptins (including kisspeptin-54 (KP-54), formerly known as metastin) are proteins encoded by the KISS1 gene in humans. Kisspeptins are ligands of the G-protein coupled receptor, GPR54. Kiss1 was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis. Kisspeptin-GPR54 signaling has an important role in initiating secretion of gonadotropin-releasing hormone (GnRH) at puberty, the extent of which is an area of ongoing research. Gonadotropin-releasing hormone is released from the hypothalamus to act on the anterior pi

protein-coding gene in the species Homo sapiens

peptide in Homo sapiens

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.

Phosducin, also known as PDC, is a human protein and gene. It belongs to the phosducin family of proteins.

Thyroid stimulating hormone, beta also known as TSHB is a protein which in humans is encoded by the TSHB gene.

mammalian protein found in Homo sapiens

Arylacetamide deacetylase-like 3 is a protein in humans that is encoded by the AADACL3 gene.

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and va

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

mammalian protein found in Homo sapiens

ADP-ribosylation factor-like protein 8A is a protein that in humans is encoded by the ARL8A gene.

Cav1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S subunit, (CACNA1S), is a protein which in humans is encoded by the CACNA1S gene. It is also known as CACNL1A3 and the dihydropyridine receptor (DHPR, so named due to the blocking action DHP has on it).

B-cell CLL/lymphoma 9 protein is a protein that in humans is encoded by the BCL9 gene.

CAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the CD52 gene.

class of enzymes

CD5 antigen-like is a protein (also known as AIM, for apoptosis inhibitor of macrophage) that in humans is encoded by the CD5L gene. It is expressed by macrophages. It regulates immune responses and inflammation. It plays a crucial role in key intracellular processes like lipid metabolism and apoptosis.