Human proteins

thumb|right | alt=Visualization of the CD58 crystallized protein from the PDB identifier 1CCZ | Visualization of the CD58 crystallized protein from the PDB identifier 1CCZ CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APCs), particularly macrophages, and other tissue cells.

MIS18 binding protein 1 is a protein that in humans is encoded by the MIS18BP1 gene. The gene is also known as LKNL2, M18BP1, C14orf106, and HSA242977. M18BP1 protein is an important component in the CENPA deposition pathway, and in most eukaryotes M18BP1 is necessary for chromosome segregation.

protein-coding gene in the species Homo sapiens

Mothers against decapentaplegic homolog 2, also known as SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.

Perilipin, also known as lipid droplet-associated protein, perilipin 1, or PLIN, is a protein that, in humans, is encoded by the PLIN gene. The perilipins are a family of proteins that associate with the surface of lipid droplets. Phosphorylation of perilipin is essential for the mobilization of fats in adipose tissue.

Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.

protein family

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

Amelogenin, Y isoform is a protein that in humans is encoded by the AMELY gene. AMELY is located on the Y chromosome and encodes a form of amelogenin. Amelogenin is an extracellular matrix protein involved in biomineralization during tooth enamel development.

Zinc finger, DHHC-type containing 14 is a protein that in humans is encoded by the ZDHHC14 gene.

Actin, gamma-enteric smooth muscle is a protein that in humans is encoded by the ACTG2 gene.

Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.

Calpain-8 is a protein in humans that is encoded by the CAPN8 gene.

BPI fold containing family B, member 4 (BPIFB4) is a protein that in humans is encoded by the BPIFB4 gene. It was formerly known as "Long palate, lung and nasal epithelium carcinoma-associated protein 4" encoded by the LPLUNC4 gene. The BPIFB4 gene sequence predicts 4 transcripts (splice variants); 3 isoforms have been well characterized. In a variety of mammals, BPIFB4 is generally expressed in very high levels in the olfactory epithelium (nasal mucosa), high levels in the gonads (testis, ovary) and pituitary, moderate levels in white blood cells (monocytes) It can occur either localized in t

Ataxin 7-like 2 is a protein in humans that is encoded by the ATXN7L2 gene.

protein-coding gene in the species Homo sapiens

Midkine (MK or MDK), also known as neurite growth-promoting factor 2 (NEGF2), is a protein that in humans is encoded by the MDK gene.

ACTC1 encodes cardiac muscle alpha actin. This isoform differs from the alpha actin that is expressed in skeletal muscle, ACTA1. Alpha cardiac actin is the major protein of the thin filament in cardiac sarcomeres, which are responsible for muscle contraction and generation of force to support the pump function of the heart.

Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene. Lin28 is a gene found in both invertebrates and vertebrates, from worms to humans, where it regulates the timing of development from fertilization to adulthood.

mammalian protein found in Homo sapiens

[[Image:endostatin.jpeg|thumb|right|Endostatin monomer, basic amino acid residues shown in red (source: pdb.org, 1KOE).]] Endostatin is a naturally occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin.

mammalian protein found in Homo sapiens

MyoD, also known as myoblast determination protein 1, is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vertebrate MRF family members include MyoD1, Myf5, myogenin, and MRF4 (Myf6). In non-vertebrate animals, a single MyoD protein is typically found.

Ankyrin-2, also known as Ankyrin-B, and Brain ankyrin, is a protein which in humans is encoded by the ANK2 gene. Ankyrin-2 is ubiquitously expressed, but shows high expression in cardiac muscle. Ankyrin-2 plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in cardiomyocytes, as well as in costamere structures. Mutations in ANK2 cause a dominantly-inherited, cardiac arrhythmia syndrome known as long QT syndrome 4 as well as sick sinus syndrome; mutations have also been associated to a lesser degree with hypertrophic cardiomyopathy. Alterat

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.

protein-coding gene in the species Homo sapiens

Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; it is also known as ALK-2 (activin receptor-like kinase-2). ACVR1 has been linked to the 2q23-24 region of the genome. This protein is important in the bone morphogenic protein (BMP) pathway that is responsible for the development and repair of the skeletal system. While knockout models with this gene are in progress, the ACVR1 gene has been connected to fibrodysplasia ossificans progressiva, an extremely rare progressive genetic disease characterized by heterotopic ossification of muscles, tendons, a

NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a process called NEDDylation similar to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The primary known substrates of NEDD8 modification are the cullin subunits of cullin-based E3 ubiquitin ligases, which are active only when NEDDylated. Their NEDDylation is critical for the recruitment of E2 to the ligase complex, thus facilitat

Neurexins (NRXN) are a family of presynaptic cell adhesion proteins that have roles in connecting neurons at the synapse. They are located mostly on the presynaptic membrane and contain a single transmembrane domain. The extracellular domain interacts with proteins in the synaptic cleft, most notably neuroligin, while the intracellular cytoplasmic portion interacts with proteins associated with exocytosis. Neurexin and neuroligin "shake hands," resulting in the connection between the two neurons and the production of a synapse. Neurexins mediate signaling across the synapse, and influence the

ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.

NOP2/Sun domain family, member 2 is a protein that in humans is encoded by the NSUN2 gene. Alternatively spliced transcript variants encoding different isoforms have been noted for the gene.

protein-coding gene in the species Homo sapiens

Neuroepithelial cell-transforming gene 1 protein is a protein that in humans is encoded by the NET1 gene.

Ficolins are pattern recognition receptors that bind to acetyl groups present in the carbohydrates of bacterial surfaces and mediate activation of the lectin pathway of the complement cascade.

Fox-1 homolog A, also known as ataxin 2-binding protein 1 (A2BP1) or hexaribonucleotide-binding protein 1 (HRNBP1) or RNA binding protein, fox-1 homolog (Rbfox1), is a protein that in humans is encoded by the RBFOX1 gene.

Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.

thumb|right|350px|Neurolign and neurexin "handshake"

RAS-like, estrogen-regulated, growth inhibitor is a protein in humans that is encoded by the RERG gene.

NEDD4 family-interacting protein 2 is a protein that in humans is encoded by the NDFIP2 gene.

Nuclear factor of activated T-cells 5, also known as NFAT5 and sometimes TonEBP, is a human gene that encodes a transcription factor that regulates the expression of genes involved in the osmotic stress.

UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.

A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c, is a protein that in humans is encoded by the ADAM10 gene.

Terminal uridylyltransferase 7 (TUT7), also known as "zinc finger, CCHC domain containing 6", is an enzyme that in humans is encoded by the ZCCHC6 gene located on chromosome 9. The ZCCHC6 protein mediates the terminal uridylation of RNA transcripts with short poly-A tails and is involved in mRNA and microRNA degradation

Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene.

Double homeobox, 4 also known as DUX4 is a protein which in humans is encoded by the DUX4 gene. Its misexpression is the cause of facioscapulohumeral muscular dystrophy (FSHD).

protein-coding gene in the species Homo sapiens

Uncharacterized protein C1orf21, also known as Proliferation-Inducing Protein 13, is a protein that in humans is encoded by the C1orf21 gene. C1orf21 is an intracellular protein that flows between the nucleus and the cytoplasm in the cell. It has been linked with cell growth and reproduction and there has been strong links with various types of cancers. There are no paralogs for this gene, however, many conserved orthologs have been found in all invertebrates. C1orf21 has low to moderate level of expression in most tissues in humans, however, it has the most expression in the skin, lung and pr

protein-coding gene in the species Homo sapiens

The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA.

Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene.

Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.

Seizure threshold 2 homolog is a protein that in humans is encoded by the SZT2 gene.

Diphosphoinositol pentakisphosphate kinase 2 is a protein that in humans is encoded by the PPIP5K2 gene.

CKLF-like MARVEL transmembrane domain-containing protein 2 (i.e. CMTM2), previously termed chemokine-like factor superfamily 2 ( i.e. CKLFSF2), is a member of the CKLF-like MARVEL transmembrane domain-containing family (CMTM) of proteins. In humans, it is encoded by the CMTM2 gene located in band 22 on the long (i.e. "q") arm of chromosome 16. CMTM2 protein is expressed in the bone marrow and various circulating blood cells. It is also highly expressed in testicular tissues: The CMTM2 gene and CMTM2 protein, it is suggested, may play an important role in testicular development.

Dpy-19-like 2 (C. elegans) is a protein that in humans is encoded by the DPY19L2 gene.