ADGRG2
Sign in to saveAlso known as EDDM6, HE6, TM7LN2, GPR64, adhesion G protein-coupled receptor G2, CBAVDX
G protein-coupled receptor 64 also known as HE6 is a protein encoded by the ADGRG2 gene. GPR64 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
In the Vinony graph
Within Vinony's link graph, ADGRG2 is referenced by 484 other articles, and connects out to PubMed, Ensembl genome database project and protein.
It sits within the topics Genes on human chromosome X and G protein-coupled receptors.
Its subject is documented across 5 Wikipedia language editions.
Gene data
ADGRG2- Name
- adhesion G protein-coupled receptor G2
- Type
- protein-coding
- Chromosome
- X
- Position
- 18,989,307–19,122,962 (−)
- Aliases
- CBAVDX, EDDM6, GPR64, HE6, TM7LN2
- Ensembl
- ENSG00000173698
- RefSeq RNA
- NM_001079858.3, NM_001079859.3, NM_001079860.3, NM_001184833.2, NM_001184834.2
- RefSeq protein
- NP_001073327.1, NP_001073328.1, NP_001073329.1, NP_001171762.1, NP_001171763.1
This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
adhesion G protein-coupled receptor G2
- Symbol
- ADGRG2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:18,989,307-19,122,962
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 4208
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10149
- chromosome
- human X chromosome
- genomic end
- 19140755
- genomic start
- 18989307
- cytogenetic location
- Xp22.13
- expressed in
- islet of Langerhans
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- External links
G protein-coupled receptor 64 also known as HE6 is a protein encoded by the ADGRG2 gene. GPR64 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
The adhesion GPCR, GPR64, is an orphan receptor characterized by a long N-terminus with that has been suggested to be highly glycosylated. GPR64's N-terminus has been reported to be cleaved at the GPS domain to allow for trafficking to the plasma membrane. After cleavage the N-terminus is believed to remain non-covalently associated with the 7TM. GPR64 expression has been mostly reported in the male reproductive organs, but more recently has been shown to be expressed in the parathyroid glands and central nervous system. GPR64 is mainly expressed in human and mouse epididymis as well as human prostate and parathyroid. GPR64, together with F-actin scaffold, locates at the nonciliated principal cells of the proximal male excurrent duct epithelia, where reabsorption of testicular fluid and concentration of sperm takes place.
Excerpted from Wikipedia’s “ADGRG2” article, available under the CC BY-SA 4.0 licence.