clofarabine
Sign in to saveAlso known as CAFdA, Cl-F-araA, Clolar®, Evoltra®, Cl-F-Ara-A, (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
Clofarabine is a purine nucleoside antimetabolite marketed in the United States and Canada as Clolar. In Europe and Australia/New Zealand the product is marketed under the name Evoltra. It is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed. Some investigations of effectiveness in cases of acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) have been carried out. Ongoing trials are assessing its efficacy for managing other cancers.
Key facts
- Drug.verifiedrevid
- 460042726
- Drug.image
- Clofarabine.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Clolar, Evoltra
- Drug.MedlinePlus
- a607012
- Drug.DailyMedID
- Clofarabine
- Drug.licence_EU
- yes
- Drug.routes_of_administration
- Intravenous
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- BB06
- Drug.legal_AU
- S4
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.CAS_number
- 123318-82-1
- Drug.PubChem
- 119182
- Drug.IUPHAR_ligand
- 6802
- Drug.DrugBank
- DB00631
via Wikipedia infobox
Research
688 papers- Clofarabine.2012
- Clofarabine.Nature reviews. Drug discovery · 2005
- Clofarabine monotherapy in aggressive, relapsed and refractory Langerhans cell histiocytosis.British journal of haematology · 2024
- Clofarabine.Drugs in R&D · 2004
- Clofarabine in leukemia.Expert review of hematology · 2010
via PubMed
Wikidata facts
- Mass
- 303.053
Show 5 more facts
- chemical formula
- C₁₀H₁₁ClFN₅O₃
- canonical SMILES
- C1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl
- isomeric SMILES
- C1=NC2=C(N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)N=C(N=C2N)Cl
- World Health Organisation international non-proprietary name
- clofarabine
- Commons category
- Clofarabine
via Wikidata · CC0
~5 min read
Article
8 sectionsContents
- Approval
- Side effects
- Contraindications
- Drug interactions
- Delivery
- Biology
- References
- External links
Clofarabine is a purine nucleoside antimetabolite marketed in the United States and Canada as Clolar. In Europe and Australia/New Zealand the product is marketed under the name Evoltra. It is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed. Some investigations of effectiveness in cases of acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) have been carried out. Ongoing trials are assessing its efficacy for managing other cancers.
==Approval== Clolar was Food and Drug Administration (FDA) approved 28 December 2004. (Under accelerated approval regulations requiring further clinical studies.)
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via Wikidata sitelinks · CC0