Clorgiline (), or clorgyline (), is a monoamine oxidase inhibitor (MAOI) and investigational antidepressant related to pargyline. Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A). Clorgiline was never marketed, but it has found use in scientific research.
Clorgiline (), or clorgyline (), is a monoamine oxidase inhibitor (MAOI) and investigational antidepressant related to pargyline. Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A). Clorgiline was never marketed, but it has found use in scientific research.
In addition to its MAOI activity, it has been found to bind with high affinity to the σ1 receptor (Ki = 3.2–510nM) and with very high affinity to the imidazoline I2 receptor (Ki = 40pM). Unlike selegiline, clorgiline does not appear to be a monoaminergic activity enhancer (MAE).
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).