Structure via PubChem · Public domain (PubChem)
clorgiline
Sign in to saveAlso known as chlorgyline, clorgyline, N-methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine, M & B 9302, M&B 9302, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-2-propynylamine, M and B 9302
Clorgiline (), or clorgyline (), is a monoamine oxidase inhibitor (MAOI) and investigational antidepressant related to pargyline. Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A). Clorgiline was never marketed, but it has found use in scientific research.
Chemical data
- Formula
- C13H15Cl2NO
- Molecular weight
- 272.17 g/mol
- IUPAC name
- 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine
- SMILES
- CN(CCCOC1=C(C=C(C=C1)Cl)Cl)CC#C
- InChIKey
- BTFHLQRNAMSNLC-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 12.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- unsaturated compound
- Mass
- 271.053
Show 5 more facts
- isomeric SMILES
- C[N@](CCCOc1ccc(cc1Cl)Cl)CC#C
- chemical formula
- C₁₃H₁₅Cl₂NO
- canonical SMILES
- CN(CCCOC1=C(C=C(C=C1)Cl)Cl)CC#C
- World Health Organisation international non-proprietary name
- clorgiline
- subject has role
- monoamine oxidase inhibitor
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Clorgiline (), or clorgyline (), is a monoamine oxidase inhibitor (MAOI) and investigational antidepressant related to pargyline. Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A). Clorgiline was never marketed, but it has found use in scientific research.
In addition to its MAOI activity, it has been found to bind with high affinity to the σ1 receptor (Ki = 3.2–510nM) and with very high affinity to the imidazoline I2 receptor (Ki = 40pM). Unlike selegiline, clorgiline does not appear to be a monoaminergic activity enhancer (MAE).
Excerpted from Wikipedia’s “clorgiline” article, available under the CC BY-SA 4.0 licence.