HMGB2

Also known as HMG2, high mobility group box 2

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.

Gene data

HMGB2

Name: high mobility group box 2
Type: protein-coding
Position: 173,331,376–173,334,456 (−)
Aliases: HMG2
Ensembl: ENSG00000164104
RefSeq RNA: NM_001130688.1, NM_001130689.1, NM_002129.4
RefSeq protein: NP_001124160.1, NP_001124161.1, NP_002120.1

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008].