MYH11
Sign in to saveAlso known as AAT4, FAA4, SMHC, SMMHC, myosin, heavy chain 11, smooth muscle, myosin heavy chain 11, VSCM2, SMMS-1
Myosin-11 is a protein that in humans is encoded by the MYH11 gene.
In the Vinony graph
Vinony's link graph records 279 inbound references to MYH11, and connects out to hair keratin, PubMed and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 16.
Vinony links it to 5 Wikipedia language editions.
Gene data
MYH11- Name
- myosin heavy chain 11
- Type
- protein-coding
- Position
- 15,703,135–15,858,438 (−)
- Aliases
- AAT4, FAA4, SMHC, SMMHC, SMMS-1, VSCM2
- Ensembl
- ENSG00000133392
- RefSeq RNA
- NM_001040113.2, NM_001040114.2, NM_002474.3, NM_022844.3, XM_054329095.1
- RefSeq protein
- NP_001035202.1, NP_001035203.1, NP_002465.1, NP_074035.1, XP_054185070.1
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. A chromosomal rearrangement involving this gene is associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4. [provided by RefSeq, May 2022].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
myosin heavy chain 11
- Symbol
- MYH11
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:15,703,135-15,858,438
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MYH11 PDB 1br1.png
Show 8 more facts
- exact match
- identifiers.org/ncbigene/4629
- HomoloGene ID
- 128512
- found in taxon
- Homo sapiens
- chromosome
- human chromosome 16
- genomic start
- 15703135
- genomic end
- 15857028
- cytogenetic location
- 16p13.11
- expressed in
- myometrium
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Function
- Clinical significance
- Acute myeloid leukemia
- Intestinal cancer
- References
- External links
- Further reading
Myosin-11 is a protein that in humans is encoded by the MYH11 gene.
== Function ==
Excerpted from Wikipedia’s “MYH11” article, available under the CC BY-SA 4.0 licence.