MYH11

Name

myosin heavy chain 11

Type

protein-coding

Position

15,703,135–15,858,438 (−)

Aliases

AAT4, FAA4, SMHC, SMMHC, SMMS-1, VSCM2

Ensembl

ENSG00000133392

RefSeq RNA

NM_001040113.2, NM_001040114.2, NM_002474.3, NM_022844.3, XM_054329095.1

RefSeq protein

NP_001035202.1, NP_001035203.1, NP_002465.1, NP_074035.1, XP_054185070.1

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. A chromosomal rearrangement involving this gene is associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4. [provided by RefSeq, May 2022].

via MyGene.info

Gene · Ensembl

myosin heavy chain 11

Symbol

MYH11

Biotype

Protein coding

Organism

Homo sapiens

Location

16:15,703,135-15,858,438

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein MYH11 PDB 1br1.png

via Wikidata · CC0