Structure via PubChem · Public domain (PubChem)
selinexor
Sign in to saveAlso known as KPT-330
Selinexor sold under the brand name Xpovio among others, is a selective inhibitor of nuclear export used as an anti-cancer medication. It works by blocking the action of exportin 1 and thus blocking the transport of several proteins involved in cancer-cell growth from the cell nucleus to the cytoplasm, which ultimately arrests the cell cycle and leads to apoptosis. It is the first drug with this mechanism of action.
Chemical data
- Formula
- C17H11F6N7O
- Molecular weight
- 443.3 g/mol
- IUPAC name
- (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide
- SMILES
- C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
- InChIKey
- DEVSOMFAQLZNKR-RJRFIUFISA-N
- XLogP
- 3
- Polar surface area
- 97.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 12
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2019
- Admin. routes
- oral
- Indications
- melanoma, dedifferentiated liposarcoma, myelodysplastic syndrome, glioblastoma multiforme
via ChEMBL · EBI
Research
695 papers- Selinexor.2012
- Selinexor.2006
- Selinexor in multiple myeloma.Expert opinion on pharmacotherapy · 2024
- Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, open-label, phase 3 trial.Lancet (London, England) · 2020
- Selinexor: First Global Approval.Drugs · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 443.093
Show 4 more facts
- canonical SMILES
- C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
- isomeric SMILES
- C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
- chemical formula
- C₁₇H₁₁F₆N₇O
- Commons category
- Selinexor
Sources (2)
via Wikidata · CC0
~14 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Adverse effects
- Mechanism of action
- Chemistry
- History
- Society and culture
- Legal status
- Research
- References
- External links
{{Infobox drug | drug_name = | INN = | type = | image = Selinexor.svg | image_class = skin-invert-image | width = | alt = Skeletal formula of selinexor | caption =
| pronounce = | tradename = Xpovio, Nexpovio | Drugs.com = | MedlinePlus = a619044 | DailyMedID = Selinexor | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category= Use should be avoided | routes_of_administration = By mouth | class = | ATCvet = | ATC_prefix = L01 | ATC_suffix = XX66 | ATC_supplemental =
Excerpted from Wikipedia’s “selinexor” article, available under the CC BY-SA 4.0 licence.