Selinexor sold under the brand name Xpovio among others, is a selective inhibitor of nuclear export used as an anti-cancer medication. It works by blocking the action of exportin 1 and thus blocking the transport of several proteins involved in cancer-cell growth from the cell nucleus to the cytoplasm, which ultimately arrests the cell cycle and leads to apoptosis. It is the first drug with this mechanism of action.
via PubMed
{{Infobox drug | drug_name = | INN = | type = | image = Selinexor.svg | image_class = skin-invert-image | width = | alt = Skeletal formula of selinexor | caption =
| pronounce = | tradename = Xpovio, Nexpovio | Drugs.com = | MedlinePlus = a619044 | DailyMedID = Selinexor | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category= Use should be avoided | routes_of_administration = By mouth | class = | ATCvet = | ATC_prefix = L01 | ATC_suffix = XX66 | ATC_supplemental =
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).