Structure via PubChem · Public domain (PubChem)
spiroxatrine
Sign in to saveAlso known as spiroxamide
Spiroxatrine (Spiroxamide, R5188) is a drug which acts as a selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor. It is an analog of spiperone and also has some dopamine antagonist effects and a relatively weak opioid action.
Chemical data
- Formula
- C22H25N3O3
- Molecular weight
- 379.5 g/mol
- IUPAC name
- 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
128 papers- Spiroxatrine derivatives towards 5-HT(1A) receptor selectivity.Pharmacological reports : PR · 2020
- Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats.Pharmacology, biochemistry, and behavior · 1989
- [3H]spiroxatrine labels a serotonin1A-like site in the rat hippocampus.Life sciences · 1987
- Serotonergic properties of spiroxatrine enantiomers.Journal of medicinal chemistry · 1988
- [3H]spiroxatrine: a 5-HT1A radioligand with agonist binding properties.Journal of neurochemistry · 1988
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 379.189592
Show 3 more facts
- chemical formula
- C₂₂H₂₅N₃O₃
- canonical SMILES
- C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CC4COC5=CC=CC=C5O4
- subject has role
- dopamine antagonist
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Spiroxatrine (Spiroxamide, R5188) is a drug which acts as a selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor. It is an analog of spiperone and also has some dopamine antagonist effects and a relatively weak opioid action.
==References==
Excerpted from Wikipedia’s “spiroxatrine” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0