spiroxatrine
Sign in to saveSpiroxatrine (Spiroxamide, R5188) is a drug which acts as a selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor. It is an analog of spiperone and also has some dopamine antagonist effects and a relatively weak opioid action.
Chemical data
- Formula
- C22H25N3O3
- Molecular weight
- 379.5 g/mol
- IUPAC name
- 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
via PubChem
Research
128 papers- Spiroxatrine derivatives towards 5-HT(1A) receptor selectivity.Pharmacological reports : PR · 2020
- Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats.Pharmacology, biochemistry, and behavior · 1989
- [3H]spiroxatrine labels a serotonin1A-like site in the rat hippocampus.Life sciences · 1987
- Serotonergic properties of spiroxatrine enantiomers.Journal of medicinal chemistry · 1988
- [3H]spiroxatrine: a 5-HT1A radioligand with agonist binding properties.
Article
1 sectionsContents
- References
Spiroxatrine (Spiroxamide, R5188) is a drug which acts as a selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor. It is an analog of spiperone and also has some dopamine antagonist effects and a relatively weak opioid action.
==References==