Talaporfin

Also known as LS11

Talaporfin (INN, also known as aspartyl chlorin, mono-L-aspartyl chlorin e6, NPe6, or LS11) is a chlorin based photosensitizer used in photodynamic therapy (PDT).

In the Vinony graph

Within Vinony's link graph, Talaporfin is referenced by 275 other articles, and connects out to tiazofurin, digital object identifier and chemical formula.

Vinony files it under Drugboxes which contain changes to verified fields, Drugs not assigned an ATC code and Drugs with non-standard legal status.

Its subject is documented across 5 Wikipedia language editions.

Chemical data

Formula: C38H41N5O9
Molecular weight: 711.8 g/mol
IUPAC name: (2S)-2-[[2-[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-17-ethenyl-12-ethyl-2,8,13,18-tetramethyl-2,3,23,24-tetrahydroporphyrin-5-yl]acetyl]amino]butanedioic acid
SMILES: CCC1=C(C2=CC3=C(C(=C(N3)C=C4[C@H]([C@@H](C(=N4)C(=C5C(=C(C(=N5)C=C1N2)C)C(=O)O)CC(=O)N[C@@H](CC(=O)O)C(=O)O)CCC(=O)O)C)C)C=C)C
InChIKey: SIEXFRDYNDREBM-BRXYURPTSA-N
XLogP: 3.5
Polar surface area: 236 Å²
H-bond donors: 7
H-bond acceptors: 11
Formal charge: 0

via PubChem

Research

300 papers

Talaporfin sodium.Expert opinion on pharmacotherapy · 2010
Clinical Practice of Photodynamic Therapy Using Talaporfin Sodium for Esophageal Cancer.Journal of clinical medicine · 2021
Talaporfin Sodium as a Clinically Translatable Radiosensitizer in Radiodynamic Therapy.Biomolecules · 2025
Combination of talaporfin photodynamic therapy and Poly (ADP-Ribose) polymerase (PARP) inhibitor in gastric cancer.Biochemical and biophysical research communications · 2021
Vascular Shutdown by Photodynamic Therapy Using Talaporfin Sodium.Cancers · 2020

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 711.2904278920003

Show 4 more facts

chemical formula: C₃₈H₄₁N₅O₉
canonical SMILES: CCC1=C2C=C3C(=C(C(=N3)C(=C4C(C(C(=N4)C=C5C(=C(C(=CC(=C1C)N2)N5)C=C)C)C)CCC(=O)O)CC(=O)NC(CC(=O)O)C(=O)O)C(=O)O)C
subject has role: photosensitizer
isomeric SMILES: C=Cc1c(C)c2cc3nc(c(CC(=O)N[C@@H](CC(=O)O)C(=O)O)c4nc(cc5[nH]c(cc1[nH]2)c(C)c5CC)C(C)=C4C(=O)O)[C@@H](CCC(=O)O)[C@@H]3C

Sources (2)

via Wikidata · CC0

~2 min read

Encyclopedic overview

1 sections

Contents

References

{{Drugbox | Verifiedfields = changed | verifiedrevid = 447519392 | IUPAC_name = N-{[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-12-ethyl-2,8,13,18-tetramethyl-17-vinyl-2,3-dihydroporphyrin-5-yl]acetyl}-L-aspartic acid | image = Talaporfin.png | image_class = skin-invert-image

Excerpted from Wikipedia’s “Talaporfin” article, available under the CC BY-SA 4.0 licence.