Structure via PubChem · Public domain (PubChem)
TC-1827
Sign in to saveTC-1827 is an orally active, selective agonist of the α4β2 nicotinic receptors. Administration of TC-1827 improved memory and learning in a variety of rodents and increased long-term potentiation in hippocampal slices. In addition, the compound was without significant cardiovascular side effects, except for a small, transient rise in arterial blood pressure. The pro-cognitive effects of TC-1827 last much longer than the short half-life (0.2–1.0 hours) would suggest.
In the Vinony graph
Vinony's link graph records 776 inbound references to TC-1827, and connects out to agonist, nicotinic acetylcholine receptor and allosteric modulator.
It sits within the topics Chembox image size set, Nicotinic agonists and Nootropics.
Vinony links it to 4 Wikipedia language editions.
Chemical data
- Formula
- C10H15N3
- Molecular weight
- 177.25 g/mol
- IUPAC name
- (E,2S)-N-methyl-5-pyrimidin-5-ylpent-4-en-2-amine
- SMILES
- C[C@@H](C/C=C/C1=CN=CN=C1)NC
- InChIKey
- VZNTWLIIJWUCEP-SGRBOOSSSA-N
- XLogP
- 1.1
- Polar surface area
- 37.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 177.12659748
Show 5 more facts
- isomeric SMILES
- C[C@H](NC)C/C=C/C1=CN=CN=C1
- chemical formula
- C₁₀H₁₅N₃
- Commons category
- TC-1827
- canonical SMILES
- CNC(C)CC=Cc1cncnc1
- subject has role
- nootropic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
TC-1827 is an orally active, selective agonist of the α4β2 nicotinic receptors. Administration of TC-1827 improved memory and learning in a variety of rodents and increased long-term potentiation in hippocampal slices. In addition, the compound was without significant cardiovascular side effects, except for a small, transient rise in arterial blood pressure. The pro-cognitive effects of TC-1827 last much longer than the short half-life (0.2–1.0 hours) would suggest.
==References==
Excerpted from Wikipedia’s “TC-1827” article, available under the CC BY-SA 4.0 licence.