UBE2C
Sign in to saveAlso known as UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C
Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.
Gene data
UBE2C- Name
- ubiquitin conjugating enzyme E2 C
- Type
- protein-coding
- Aliases
- UBCH10, dJ447F3.2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013].
via MyGene.info
Wikidata facts
- Image
- Protein UBE2C PDB 1i7k.png
Show 5 more facts
- HomoloGene ID
- 5096
- exact match
- identifiers.org/ncbigene/11065
- genomic end
- 44445596
- genomic start
- 44441215
- cytogenetic location
- 20q13.12
Sources (4)
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- Further reading
Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.