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benzamil
Sign in to saveBenzamil or benzyl amiloride is a potent blocker of the ENaC channel and also a sodium-calcium exchange blocker. It is a potent analog of amiloride, and is marketed as the hydrochloride salt (benzamil hydrochloride). As amiloride, benzamil has been studied as a possible treatment for cystic fibrosis, although with disappointing results.
Wikidata facts
- Mass
- 319.094836
Show 4 more facts
- chemical formula
- C₁₃H₁₄ClN₇O
- isomeric SMILES
- N/C(=N\C(=O)C1=NC(Cl)=C(N)N=C1N)/NCC2=CC=CC=C2
- canonical SMILES
- C1=CC=C(C=C1)CN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
- Commons category
- Benzamil
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Article
4 sectionsContents
- Structure
- Mechanism of action
- References
- External links
Benzamil or benzyl amiloride is a potent blocker of the ENaC channel and also a sodium-calcium exchange blocker. It is a potent analog of amiloride, and is marketed as the hydrochloride salt (benzamil hydrochloride). As amiloride, benzamil has been studied as a possible treatment for cystic fibrosis, although with disappointing results.
==Structure== Benzamil is a benzyl group-containing analog of amiloride. Like amiloride, it is a guanidinium group-containing pyrazine derivative.