Structure via PubChem · Public domain (PubChem)
dotarizine
Sign in to saveDotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A and 5HT2C receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has some anxiolytic effects and blocks amnesia produced by electroconvulsive shock in animals.
In the Vinony graph
Within Vinony's link graph, dotarizine is referenced by 1,766 other articles, and connects out to valproic acid, N-methylserotonin and (RS)-baclofen.
It sits within the topics Antimigraine drugs, Calcium channel blockers and Chemical pages without DrugBank identifier.
Its subject is documented across 6 Wikipedia language editions.
Chemical data
- Formula
- C29H34N2O2
- Molecular weight
- 442.6 g/mol
- IUPAC name
- 1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
- SMILES
- C1CN(CCN1CCCC2(OCCO2)C3=CC=CC=C3)C(C4=CC=CC=C4)C5=CC=CC=C5
- InChIKey
- LRMJAFKKJLRDLE-UHFFFAOYSA-N
- XLogP
- 4.9
- Polar surface area
- 24.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- carbon
- Mass
- 442.262
- Has use
- medication
Show 3 more facts
- chemical formula
- C₂₉H₃₄N₂O₂
- canonical SMILES
- C1CN(CCN1CCCC2(OCCO2)C3=CC=CC=C3)C(C4=CC=CC=C4)C5=CC=CC=C5
- subject has role
- tranquilizer
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Dotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A and 5HT2C receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has some anxiolytic effects and blocks amnesia produced by electroconvulsive shock in animals.
== References ==
Excerpted from Wikipedia’s “dotarizine” article, available under the CC BY-SA 4.0 licence.