Fotemustin

Arzneistoff

In the Vinony graph

Within Vinony's link graph, Fotemustin is referenced by 275 other articles, and connects out to tiazofurin, medication and digital object identifier.

Vinony files it under Chloroethyl compounds, Drugboxes which contain changes to verified fields and ECHA InfoCard ID from Wikidata.

Its subject is documented across 11 Wikipedia language editions.

Chemical data

Formula: C9H19ClN3O5P
Molecular weight: 315.69 g/mol
IUPAC name: 1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
SMILES: CCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC
InChIKey: YAKWPXVTIGTRJH-UHFFFAOYSA-N
XLogP: 0.9
Polar surface area: 97.3 Å²
H-bond donors: 1
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Small molecule
Indications: neoplasm, glioblastoma multiforme, cutaneous melanoma, melanoma

via ChEMBL · EBI

Research

415 papers

Fotemustine for the treatment of melanoma.Expert opinion on pharmacotherapy · 2011
Fotemustine in the treatment of brain primary tumors and metastases.Cancer investigation · 1994
Fotemustine in recurrent high‑grade glioma: MRI neuro‑radiological findings.Oncology letters · 2024
An overview of fotemustine in high-grade gliomas: from single agent to association with bevacizumab.BioMed research international · 2014
Focus on Fotemustine.Journal of experimental & clinical cancer research : CR · 2006

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 315.075
Has use: medication

Show 4 more facts

chemical formula: C₉H₁₉ClN₃O₅P
canonical SMILES: CCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC
subject has role: antineoplastic
Commons category: Fotemustine

Sources (2)

via Wikidata · CC0

Article · Deutsch

Fotemustin, chemisch 1-(2-Chlorethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosoharnstoff (Handelsname Muphoran), ist der Freiname für ein Zytostatikum aus der Gruppe der Nitrosoharnstoffe. Es ist für die Behandlung von disseminiert metastasierten Melanomen zugelassen.

Abstract from DBpedia / Wikipedia · CC BY-SA