Structure via PubChem · Public domain (PubChem)
glafenine
Sign in to saveAlso known as Glifanan, Glycerylaminophenaquine, 4-((2-Carboxyphenyl)amino)-7-chloroquinoline alpha-monoglyceride, 2,3-Dihydroxypropyl N-(7-chloro-4-quinolyl) anthranilate, 4-(2'-beta,gamma-Dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline, Glaphenin, Glifan, Glaphenine
Glafenine is a nonsteroidal anti-inflammatory drug (NSAID). Use of glafenine is limited due to the risk of anaphylaxis and acute kidney failure.
In the Vinony graph
Within Vinony's link graph, glafenine is referenced by 490 other articles, and connects out to salicylic acid, metamizole sodium and clonixin.
It is catalogued under topics including Anthranilates, Chemical pages without DrugBank identifier and Chloroarenes.
Its subject is documented across 9 Wikipedia language editions.
Chemical data
- Formula
- C19H17ClN2O4
- Molecular weight
- 372.8 g/mol
- IUPAC name
- 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate
- SMILES
- C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC(=CC3=NC=C2)Cl
- InChIKey
- GWOFUCIGLDBNKM-UHFFFAOYSA-N
- XLogP
- 3.5
- Polar surface area
- 91.7 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- Fever, pain
via ChEMBL · EBI
Research
207 papers- [Glafenine hepatotoxicity].Medicina clinica · 1988
- Hepatotoxicity of glafenine.Lancet (London, England) · 1978
- [Shock caused by glafenine. Apropos of 7 complications].La Revue de medecine interne · 1989
- The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway.Scientific reports · 2022
- Bioactivation of glafenine by human liver microsomes and peroxidases: identification of electrophilic iminoquinone species and GSH conjugates.Drug metabolism and disposition: the biological fate of chemicals · 2011
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 372.088
Show 3 more facts
- canonical SMILES
- C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC(=CC3=NC=C2)Cl
- chemical formula
- C₁₉H₁₇ClN₂O₄
- World Health Organisation international non-proprietary name
- glafenine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Glafenine is a nonsteroidal anti-inflammatory drug (NSAID). Use of glafenine is limited due to the risk of anaphylaxis and acute kidney failure.
== See also == Floctafenine, a chemically related NSAID
Excerpted from Wikipedia’s “glafenine” article, available under the CC BY-SA 4.0 licence.
Available in 9 languages
via Wikidata sitelinks · CC0