Structure via PubChem · Public domain (PubChem)
LP-44
Sign in to saveAlso known as compound 5 [PMID 17649988]
LP-44 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor. While LP-44 is less selective than the related compound LP-12, it has been more widely used in research and has been used to show the complex role of 5-HT7 receptors in several aspects of brain function, including regulation of the sleep-wake cycle and roles in stress, learning and memory.
In the Vinony graph
Vinony's link graph records 1,367 inbound references to LP-44, and connects out to N-methylserotonin, 5-HT receptor and (Z)-thiothixene.
It is catalogued under topics including 1-Aminotetralins, 5-HT7 agonists and Chemical pages without DrugBank identifier.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C27H37N3OS
- Molecular weight
- 451.7 g/mol
- IUPAC name
- 6-[4-(2-methylsulfanylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide
- SMILES
- CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
- InChIKey
- JNBBJUHCODFLEG-UHFFFAOYSA-N
- XLogP
- 5
- Polar surface area
- 60.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 451.265734
Show 2 more facts
- chemical formula
- C₂₇H₃₇N₃OS
- canonical SMILES
- CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
LP-44 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor. While LP-44 is less selective than the related compound LP-12, it has been more widely used in research and has been used to show the complex role of 5-HT7 receptors in several aspects of brain function, including regulation of the sleep-wake cycle and roles in stress, learning and memory.
==See also== AS-19 E-55888 LP-211
Excerpted from Wikipedia’s “LP-44” article, available under the CC BY-SA 4.0 licence.