ADGRE3

Also known as EMR3, adhesion G protein-coupled receptor E3

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene. EMR3 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Gene data

ADGRE3

Name: adhesion G protein-coupled receptor E3
Type: protein-coding
Aliases: EMR3

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014].

via MyGene.info

Wikidata facts

Show 5 more facts

HomoloGene ID: 50009
exact match: identifiers.org/ncbigene/84658
genomic end: 14800839
genomic start: 14729929
cytogenetic location: 19p13.12

Sources (3)

via Wikidata · CC0

~1 min read

Article

4 sections

Contents

Function
Ligands
References
External links

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human. Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain. Mice, next to Emr2, lack the Emr3 gene.