Structure via PubChem · Public domain (PubChem)
Iodo-Willardiine
Sign in to save5-Iodowillardiine is a selective agonist for some kainate receptor subunits with only limited effects at AMPA receptors. It activates kainate receptors containing GluK1 (GluR5) or GluK5 (KA2) subunits, but it does not act on GluK2 (GluR6) subunits. It is an excitotoxic neurotoxin in vivo, but has proved highly useful for characterising the subtypes and function of the various kainate receptors in the brain and spinal cord.
In the Vinony graph
Vinony's link graph records 320 inbound references to Iodo-Willardiine, and connects out to AMPA receptor, pentamidine and 1-aminocyclopropanecarboxylic acid.
It sits within the topics 2,3-Diaminopropionic acids, Amino acid derivatives and Chembox image size set.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C7H8IN3O4
- Molecular weight
- 325.06 g/mol
- IUPAC name
- (2S)-2-amino-3-(5-iodo-2,4-dioxopyrimidin-1-yl)propanoic acid
- SMILES
- C1=C(C(=O)NC(=O)N1C[C@@H](C(=O)O)N)I
- InChIKey
- AXXYLTBQIQBTES-BYPYZUCNSA-N
- XLogP
- -3.7
- Polar surface area
- 113 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 324.956
Show 3 more facts
- chemical formula
- C₇H₈IN₃O₄
- isomeric SMILES
- C1=C(C(=O)NC(=O)N1C[C@@H](C(=O)O)N)I
- canonical SMILES
- C1=C(C(=O)NC(=O)N1CC(C(=O)O)N)I
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
5-Iodowillardiine is a selective agonist for some kainate receptor subunits with only limited effects at AMPA receptors. It activates kainate receptors containing GluK1 (GluR5) or GluK5 (KA2) subunits, but it does not act on GluK2 (GluR6) subunits. It is an excitotoxic neurotoxin in vivo, but has proved highly useful for characterising the subtypes and function of the various kainate receptors in the brain and spinal cord.
==References==
Excerpted from Wikipedia’s “Iodo-Willardiine” article, available under the CC BY-SA 4.0 licence.