اسپیراپریل

Also known as Renormax®, SCH-33844

Spirapril, sold under the brand name Renormax among others, is an ACE inhibitor antihypertensive drug used to treat hypertension. It belongs to dicarboxy group of ACE inhibitors.

In the Vinony graph

Within Vinony's link graph, اسپیراپریل is referenced by 81 other articles, and connects out to angiotensins, amlodipine/valsartan and antihypertensive drug.

It sits within the topics 1,3-Dithiolanes, ACE inhibitors and Carboxamides.

Its subject is documented across 14 Wikipedia language editions.

Chemical data

Formula: C22H30N2O5S2
Molecular weight: 466.6 g/mol
IUPAC name: (8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3(C[C@H]2C(=O)O)SCCS3
InChIKey: HRWCVUIFMSZDJS-SZMVWBNQSA-N
XLogP: 0.9
Polar surface area: 147 Å²
H-bond donors: 2
H-bond acceptors: 8
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1994
Admin. routes: oral
Indications: cardiovascular disease

via ChEMBL · EBI

Research

147 papers

Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension.Drugs · 1995
Efficacy and safety of spirapril in mild-to-moderate hypertension.Journal of cardiovascular pharmacology · 1999
Angiotensin-converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2023
Comparison of efficacy of spirapril and enalapril in control of mild-to-moderate hypertension.Cardiovascular drugs and therapy · 1997
ACE inhibition in chronic renal failure and in the treatment of diabetic nephropathy: focus on spirapril.Journal of cardiovascular pharmacology · 1999

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 466.16
Has use: medication

Show 6 more facts

chemical formula: C₂₂H₃₀N₂O₅S₂
canonical SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3(CC2C(=O)O)SCCS3
isomeric SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3(C[C@H]2C(=O)O)SCCS3
defined daily dose: 6
Commons category: Spirapril
subject has role: ACE inhibitor

Sources (3)

via Wikidata · CC0