nefazodone
Sign in to saveAlso known as BMY-13754, MJ-13754-1, 1-{3-[4-(m-chlorophenyl)-1-piperazinyl]propyl}-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one
Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant medication which is used in the treatment of depression and for other uses. Nefazodone was withdrawn in most countries by 2004 (due to liver toxicity). On December 2021, it was published that despite shortage it is still available in the United States.As of February 2026 it is available in the United States in generic form. The medication is taken by mouth.
Research
829 papers- Nefazodone.2012
- Nefazodone: a new antidepressant.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 1995
- Nefazodone: its place among antidepressants.The Annals of pharmacotherapy · 1996
- Clinical pharmacokinetics of nefazodone.Clinical pharmacokinetics · 1997
- Nefazodone-induced mania.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 1995
via PubMed
Wikidata facts
- Mass
- 469.224
Show 5 more facts
- chemical formula
- C₂₅H₃₂ClN₅O₂
- canonical SMILES
- CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl
- World Health Organisation international non-proprietary name
- nefazodone
- defined daily dose
- 0.4
- Commons category
- Nefazodone
Sources (6)
via Wikidata · CC0
~11 min read
Article
16 sectionsContents
- Medical uses
- Available forms
- Contraindications
- Side effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Research
- References
- External links
Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant medication which is used in the treatment of depression and for other uses. Nefazodone was withdrawn in most countries by 2004 (due to liver toxicity). On December 2021, it was published that despite shortage it is still available in the United States.As of February 2026 it is available in the United States in generic form. The medication is taken by mouth.
Side effects of nefazodone include dry mouth, sleepiness, nausea, dizziness, blurred vision, weakness, lightheadedness, confusion, and postural low blood pressure, among others. Rarely, nefazodone can cause serious liver damage, with an incidence of death or liver transplantation of about 1 in every 250,000 to 300,000 patient years. Nefazodone is a phenylpiperazine compound and is related to trazodone. It has been described as a serotonin antagonist and reuptake inhibitor (SARI) due to its combined actions as a potent antagonist of the serotonin 5-HT2A and 5-HT2C receptors and weak serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI).