Structure via PubChem · Public domain (PubChem)
naftopidil
Sign in to saveNaftopidil (INN, marketed under the brand name Flivas) is a drug used in benign prostatic hyperplasia which acts as a selective α1-adrenergic receptor antagonist or alpha-1 blocker.
In the Vinony graph
Vinony's link graph records 985 inbound references to naftopidil, and connects out to propranolol, atenolol and adrenergic receptor.
It is catalogued under topics including 2-Methoxyphenyl compounds, Alpha-1 blockers and Antihypertensive agents.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C24H28N2O3
- Molecular weight
- 392.5 g/mol
- IUPAC name
- 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol
- SMILES
- COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
- InChIKey
- HRRBJVNMSRJFHQ-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 45.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1999
- Admin. routes
- oral
- Indications
- hyperplasia
via ChEMBL · EBI
Research
317 papers- Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia.The Cochrane database of systematic reviews · 2018
- Naftopidil for the treatment of benign prostate hyperplasia: a systematic review.Current medical research and opinion · 2014
- Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia.The Cochrane database of systematic reviews · 2009
- Drug Repositioning of the α(1)-Adrenergic Receptor Antagonist Naftopidil: A Potential New Anti-Cancer Drug?International journal of molecular sciences · 2020
- Naftopidil reduced the proliferation of lung fibroblasts and bleomycin-induced lung fibrosis in mice.Journal of cellular and molecular medicine · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 392.21
Show 4 more facts
- subject has role
- platelet aggregation inhibitors
- chemical formula
- C₂₄H₂₈N₂O₃
- canonical SMILES
- COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
- Commons category
- Naftopidil
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Naftopidil (INN, marketed under the brand name Flivas) is a drug used in benign prostatic hyperplasia which acts as a selective α1-adrenergic receptor antagonist or alpha-1 blocker.
==Synthesis== upright=2|class=skin-invert-image
Excerpted from Wikipedia’s “naftopidil” article, available under the CC BY-SA 4.0 licence.